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NanoSIMS-HR

과학 및 첨단 기술을 위한 나노분석의 차세대 개척지

NanoSIMS-HR은 재료 과학, 반도체, 지구화학, 우주화학 등 다양한 기초 연구 및 산업 혁신 분야에서 주요 발전에 기여한 세계적으로 인정받는 NanoSIMS 50/50L 2차 이온 질량 분석기 시리즈의 차세대 제품입니다. 식물 및 토양 과학, 환경 미생물학, 세포 생물학 및 의학 연구.

새로운 NanoSIMS-HR을 통해 CAMECA는 이 고유한 이온 마이크로프로브의 다양성을 높이고, 데이터 품질을 향상시키며, 과학자와 엔지니어가 계속 증가하는 작업량과 촉박한 기한 속에서 발견과 혁신을 가속화할 수 있도록 획기적인 도구 혁신을 제공합니다.
  • 제품 개요 +


    NanoSIMS-HR의 주요 개선 사항과 새로운 기능은 다음과 같습니다.

    최고의 샘플 충실도
    • 새로운 세슘 공급원과 진동 방지 격리 기능을 갖춘 재설계된 플랫폼 덕분에 전례 없는 측면 분해능(30 nm)
    • 기기 튜닝을 용이하게 하는 새로운 전자 장치 덕분에 8 x 8 µm2 영역의 깊이 프로파일에 대해 10년당 12 nm까지 깊이 분해능 제공
    • 글로브박스 및 극저온 액세서리를 사용한 깨끗한 시료 분석


    처리량 향상
    • 더 높은 전류 밀도와 더 밝은 세슘 소스 덕분에 100nm 측면 해상도에서 2.5배 더 빠른 이미지 획득
    • 다양한 대형 샘플 홀더가 이제 다양한 크기의 더 많은 샘플을 수용할 수 있습니다.
    • 10배 더 정확한 샘플 스테이지로 더 작은 이미지를 더 빠르게 획득할 수 있어 무인 연결 분석이 10배 더 빨라집니다.


    사용의 용이성
    • 보관소에서 분석실로 자동 도입
    • 3.6 x 4 mm2 광학 이미지를 통해 관심 영역을 직접 타겟팅하기 위한 쉽고 정확한 탐색
    • 피크 센터링 및 튜닝 최적화를 촉진하는 새로운 고해상도 전자 장치
    • 여러 시료 보유자가 필요한 대규모 분석 세션을 촉진하는 원격 작업


    신뢰성 및 가동 시간
    • 최적의 냉각 시스템으로 업그레이드된 Rf-Plasma O-소스
    • 최신 Pfeiffer 터보분자 및 1차 펌프
    • 재설계된 고전압 전원 공급 장치를 포함한 새로운 제어 전자 장치
  • NanoSIMS 활용 사례 +

  • 자료 및 연구 사례 +

  • 최근 웨비나 보기 +

    • Revealing the intracellular distributions of biomolecules with a novel NanoSIMS-based methodology

      화요일, 6월 18, 2024

      Melanie Brunet, Ph.D. candidate in the Department of Chemical and Biomolecular Engineering at the University of Illinois Urbana−Champaign, working under the guidance of Prof. Mary Kraft, will introduce you to new NanoSIMS-based methodology that significantly enhances the accuracy of intracellular biomolecule visualization. Key take aways include: • Advanced Depth Correction • Accuracy in Imaging • Validation and Impact • Research Applications. .
      Duration: 30 minutes
      Click here to view
    • Lithium-ion battery research with NanoSIMS

      금요일, 3월 1, 2024

      Gina Greenidge, Higher Scientist at the National Physical Laboratory (NPL), UK’s National Metrology Institute, presents a study nitrogen fixation in maize leaf chloroplasts, or the role of vitamin B5 on cancer tumor proliferation. Key take aways include: • Review the capabilities of the NanoSIMS for nanoscale chemical mapping in LIB samples • Observe the collocation of fluorine and phosphorus, and the increase in Li, P and F signals for aged LIB samples • Gain insight into LIB anode degradation processes and the challenges that lie ahead for enabling batteries with longer life-time and higher performane .
      Duration: 32 minutes
      Click here to view
    • Improving the targeting of ASO therapeutic by NanoSIMS sub-cellular imaging

      금요일, 2월 23, 2024

      Cécile Becquart, post-doctoral fellow at AstraZeneca, presents recent advances in Antisense Oligonucleotides (ASOs) and the use of NanoSIMS to image and quantify the distribution and accumulation of ASOs within cells. Key take aways include: • Review challenges in terms of delivery of ASOs to specific tissues and inefficient escape from endolysosomal compartments which restrict their use in the clinic • Understand the mechanisms underlying how ASOs enter cells and exit the endolysosomal space • Learn about the specifics NanoSIMS sub-cellular quantitative imaging .
      Duration: 18 minutes
      Click here to view
  • 전세계의 NanoSIMS 사용자 +

    Below are links to some of our NanoSIMS Users
    If your site is not listed and you would like to appear on this page, please contact cameca.info@ametek.com.

    Stanford Nano Shared Facilities (SNSF), CA, USA
    NSF provides shared scientific instrumentation, laboratory facilities, and expert staff support to enable multidisciplinary research and educate tomorrow’s scientists and engineers.

    NASA, Astromaterials Research & Exploration Science, Houston TX, USA
    The ARES scientists are dedicated to astromaterials research (meteorites, cosmic and interplanetary dust, solar wind, and lunar rocks), exobiology & organic geochemistry. They use a NanoSIMS 50L to uncover insights on processes of early solar system and stellar evolution.

    Lawrence Livermore National Laboratory, California, USA
    The NanoSIMS at LLNL is used in groundbreaking microbiological research: it helps studying microbial nitrogen and carbon fixation, and carbon cycling, investigating forensic signatures in bacterial spores, vegetative cells, viruses, as well as a range of nuclear materials..

    CalTech Center for Microanalysis, USA
    The Center for Microanalysis at Caltech houses a NanoSIMS 50L and an IMS 7f-GEO, providing expertise for microanalysis of geological, meteoritic and synthetic materials. Research projects carried out at CCM are most varied, ranging from cosmochemistry to experimental studies on climate change, geochronology, in-situ studies of microbial communities, materials science engineering, and more...

    Center for NanoImaging, Brigham and Women's Hospital, USA
    Our mission is to extend multi-isotope imaging mass spectrometry – or MIMS – to new areas of biology and biomedical research, including with human translational studies conducted at the Brigham and Women’s Hospital and collaborating medical centers.

    Arizona State University, Tempe, USA
    Funded by the National Science Foundation and ASU, the NanoSIMS lab at ASU is mainly in space sciences, to investigate the chemistry of asteroids and comets.

    Washington University in Saint-Louis, MI, USA
    The Laboratory for Space Sciences at Washington University received the first NanoSIMS in 2000. Research projects cover presolar grains, interplanetary dust particles, meteorite geochemistry etc.

    Environmental Molecular Science Laboratory, Richland, WA, USA
    EMSL, a national scientific user facility at Pacific Northwest National Laboratory has been equipped with a NanoSIMS 50L model since 2011.

    Manchester University, School of Materials, UK
    The NanoSIMS 50L is a major component of the Multi-Disciplinary Characterisation Facility, and is applied across a wide range of projects in advanced materials research, geological investigations of interest to the nuclear,oil and gas sectors, as well as the study of extra-terrestrial materials, but also tracing biochemical processes in microbes and plants.

    Open University, UK
    The NanoSIMS 50L lab in Milton Keynes is managed by Dr I.A. Franchi, and used primarily for characterizing fine grained material and cometary dust particles collected in the stratosphere.

    The Department of Materials, University of Oxford, UK
    The CAMECA NanoSIMS 50 is an ultra high resolution chemical imaging facility combining the sensitivity of a dynamic SIMS with a lateral resolution of about 100nm. Our machine was delivered in August 2002 and is used on a very wide range of projects in the analysis of metallic, semiconducting, polymeric and biological materials....

    National Physical Laboratory (NPL), UK
    NPL is home to the National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI), which aims to advance the development, understanding and application of the principal mass spectrometry imaging techniques. NPL researchers use the NanoSIMS 50L to support customers in healthcare, life sciences and other industries.

    Max Planck Institute for Chemistry, Cosmochemistry Department, Mainz, Germany
    The Cosmochemistry Department consists of several groups of scientists and technical personnel whose research interests and activities span a wide variety of fields in cosmochemical and space sciences. Many abstracts in the astrophysics field, downloadable in pdf format

    Max Planck Institut, Bremen, Germany

    The Max Planck Institute for Marine Microbiology of Bremen hosts the first NanoSIMS dedicated to environmental microbiology.

    Leibniz Institute for Baltic Sea Research (IOW), Warnemünde, Germany
    The NanoSIMS 50L at IOW is applied to a wide range of research fiels from microbiology and medicine to particle analysis and soil science.

    TUM: Technische Universität München, Germany
    Research Department Ecology and Ecosystem Management. Soil is the focal and connecting link between the information, matter and energy cycles of the hydrogeosphere and the atmosphere. Soil organic matter, clay sized particles and iron oxides are the most important reactants in soils building a complex physico-chemical interface. (…)

    Helmholtz Centre for Environmental Research – UFZ Leipzig, Germany
    Department of Isotope Biogeochemistry.
    What is the role of biogeochemical processes in the functionality of sustainably managed ecosystems? How can stable isotope readings assist the understanding of the fate of chemicals in anoxic environments such as soil-aquifer systems, freshwater and deep-sea sediments and bioreactors?

    University Medical Center Goettingen (UMG), Germany
    The University of Göttingen NanoSIMS was acquired in 2017 to equip the Center for Biostructural Imaging of Neurodeegneration (BIN).It is mainly applied to  the imaging of specific biological organelles, and thus provides insights into local protein and organelle turnover in a variety of cells and tissues.

    Faculty of Life Science, University of Vienna, Austria
    Inaugurated in February 2010, the NanoSIMS 50L lab is located within the Core Facility for Advanced Isotope Research. Under leadership from Michael Wagner, the Department of Microbial Ecology is one of the world leading center for single cell microbiology and the study of microorganisms in selected ecosystems.

    UPFL: Université Polytechnique Fédérale de Lausanne, Switzerland
    Laboratory for Biological Geochemistry LGB. Established in 2012, the LBG currently consists of about 15 Senior Scientists, Postdocs, PhD- and Master students working on research projects at the interface between isotope geochemistry, mineralogy and biology.

    LIST, Luxembourg institute of Science and Technology, Luxembourg
    The Luxembourg Institute of Science and Technology (LIST) is a mission-driven Research and Technology Organisation (RTO) that develops advanced technologies and delivers innovative products and services to industry and society.

    Utrecht University, Netherlands
    Since summer 2013 Utrecht University hosts the Dutch national facility for high-resolution in situ isotope and element analysis of natural materials, supporting research in biogeochemistry and (microbial) ecology, paleo-environmental and climate reconstructions, planetary and solid earth sciences.
    > Watch video on NanoSIMS

    Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie (IMPMC), Paris, France
    The IMPMC is particularly notable in its multidisciplinary approach. This means most topics are studied by researchers from different backgrounds—in physics, Earth science or biology. Experimental platforms, technical know-how and scientific expertise are all used to conduct research on the interactions between the living world (including bacteria) and the mineral world.

    Institut Curie, Orsay, France
    Analytical Imaging of the Cell by Secondary Ion Mass Spectroscopy (SIMS microscopy). Introduction: "Of the various analytical methods developed in microscopy during the latter half of the century, SIMS imaging is probably one of the most powerful and sophisticated. Originally introduced..." Link to full article.

    Groupe de Physique des Matériaux (GPM), Rouen, France
    The NanoSIMS at GPM supports multidisciplinary projects in the field of health and environment: human exposure to nanoparticles and their dispersion in the environment, interactions of (nano)particles with living organisms in connection with toxicological and cosmetological studies.

    IPREM, Université of Pau, France

    The NanoSIMS 50L at Institute of Analytical Sciences and Physico-Chemistry for Environment and Materials (IPREM) is the first one equipped with the new RF Plasma oxygen ion source. It is mainly used for the localization of metals at catalyst surfaces or the imaging of essential and toxic trace metals in biological cells.

    Chemical Imaging Infrastructure of the Gothenburg University and Chalmers University of Technology, Sweden
    The NanoSIMS 50L in Gothenburg is the first of these instruments in Scandinavia. The NanoSIMS is suitable for a wide variety of applications such as grain boundary analysis, characterization of stress corrosion cracking, sub-cellular drug/peptide imaging and nitrogen fixation studies in bacteria.

    Physical Research Laboratory, India
    Known as the cradle of Space Sciences in India, the Physical Research Laboratory (PRL) was founded in 1947 by Dr. Vikram Sarabhai. As a unit of the Department of Space, Government of India, PRL carries out fundamental research in select areas of Physics, Space & Atmospheric Sciences, Astronomy, Astrophysics & Solar Physics, and Planetary & Geosciences.

    IGGCAS, Beijing, China
    The Institute of Geology and Geophysics, Chinese Academy of Sciences houses a NanoSIMS 50L in addition to its 2 large-geometry SIMS (IMS 1280 and IMS 1280-HR). The NanoSIMS was acquired to promote research in space sciences and is meant to play a major role in the analysis of lunar samples retrieved by Chinese lunar exploration missions.

    Academia Sinica, Taipei, Taiwan
    The NanoSIMS Laboratory was established in 2013 by a cooperative effort between Institute of Astronomy and Astrophysics and the Institute of Earth Science of Academia Sinica. Primarily designed to probe the early Solar System by analyzing extraterrestrial and terrestrial samples, the laboratory is also involved in numerous interdisciplinary collaborations with both domestic and international research groups covering cosmo, geo, life and material sciences.

    Kochi Institute for Core Research Sample, JAMSTEC, Japan
    The Isotope Geochemistry Group owns several CAMECA SIMS dedicated to the analysis of isotopes and trace elements in geological, environmental and biological samples to understand water-rock interactions, geologic processes, global & regional geochemical cycles, and limits of subseafloor life.

    Toray Research Center, Japan
    Established in 2018, the NanoSIMS 50 L lab offers analytical service in semiconductor, ceramics, metal and life science areas.

    Centre for Microscopy, Characterization & Analysis, UWA, Perth, Autralia
    Established in 1970, the CMCA provides essential teaching and research infrastructure in ion, electron, laser and light microscopy and microanalysis to universities, goverment of Western Australia and local industry. It is now home to two CAMECA ion probes, the NanoSIMS 50 installed in 2003 and the more recently acquired IMS 1280.
  • 소프트웨어 +

    • WinCurve dataprocessing sofware
      WinCurve

      CAMECA SIMS 장비용으로 특별히 개발된 WinCurve는 사용자 친화적인 환경에서 강력한 데이터 처리 및 시각화 기능을 제공합니다.

      Keep Reading

    • WinImage Software
      WinImage II

      CAMECA SIMS 기비용으로 특별히 개발된 WinImage II는 PC-Windows™ 환경에서 강력한 이미지 시각화, 처리 및 인쇄 기능을 제공합니다

      Keep Reading

  • 과학 간행물 +


    An Excel spreadsheet compiling scientific research articles using NanoSIMS data is available for download. The articles are ordered by main applications as below and are easily searchable with Excel word search functions:
    • Planetary Sciences
    • Geology
    • Geochronology
    • Paleobiology / Evolution
    • Atmospheric particles / Aerosols
    • Biomineralization / Paleoclimate
    • Environment / Nanoparticles
    • Soils
    • Plants
    • Environmental Microbiology
    • Microbiome / Microbiology
    • Cell Biology
    • Pharmacology / Cosmetics
    • Materials
    • Methods / Instrumentation
    Click here to download the NanoSIMS scientific articles compilation spreadsheet

    Do not hesitate to contact us at cameca.info@ametek.com if you can not access some pdf files by your own. You are also more than welcome to send us any missing references, pdf and supplements!